The Role of curcumin extract in Ameliorating Cyclophosphamide-Induced Cardiotoxicity

Cyclophosphamide, a chemotherapeutic and immunosuppressive drug, has been linked to problems after bone marrow transplantation in the past. More recently, it demonstrated that cardiotoxicity limits dose of cyclophosphamide, cardiology is receiving more attention. Though exact mechanism cyclophosphamide-induced unknown, oxidative nitrative stress are suspected play role. As result, focus this review on antioxidants how they can reduce or prevent cardiotoxicity. It will place special emphasis cardioprotective properties naturally occurring, plant-derived such as curcumin extract, which have recently attracted lot interest.